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The Kunitz domain may perhaps exist singly, or as numerous domains in a one polypeptide [three]. a lot of Kunitz domains act as protease inhibitors by way of their scissile bond at positions 15 (P1) and 16 (P1′). The P1 residue is frequently a standard amino acid (K or R) whilst the P1′ situation is an A or G, which collectively interact with the Lively internet site of a number of proteases [one]. option modes of motion have also been characterised. such as, snake venoms contain Kunitz relatives proteins named dendrotoxins that show weak anti-protease action but strongly block neuronal K+ channels [four].